Organic Synthesis (3) Theory and methodology of organic synthesis applied to complex organic molecules.
CHEM 474 Organic Synthesis (3)
CHEM 474 will present the theory and methodology of organic synthesis. The course will initially focus on the methodology necessary to synthesize complex organic molecules. This will include an in-depth look at functional group transformations, carbon-carbon bond forming reactions, ring-forming reactions, aromatic chemistry and heterocyclic chemistry. We will then discuss the use of retrosynthetic analysis and the "disconnection approach" to logically guide total synthesis. Finally, a number of literature syntheses will be used to examine the strategies involved in formulating a total synthesis emphasizing the compatibility of functional groups, sequence of reactions, use of protecting groups and the impact of stereochemistry.
Note : Class size, frequency of offering, and evaluation methods will vary by location and instructor. For these details check the specific course syllabus.