Surfaces and the Biological Response to Materials (3) Focus is on the special properties of surfaces as an important causative and mediating agent in the biological response to materials.
MATSE 404 (BIOE 444) Surfaces and the Biological Response to Materials (3)
This course factors the classical picture of the biological response to materials into spatial and temporal components, identifying the special properties of surfaces as an important causative and mediating agent. Biophysical mechanisms are emphasized that lead to formulation of structure property relationships and the biological response to materials. Contact activation of the blood plasma coagulation cascade, bioadhesion, and protein adsorption are used as example biological responses to material surfaces to illustrate concepts and principles. Leading theories attempting to correlate both kind and intensity of biological responses to surface and interfacial energetics will be compared and contrasted through a process that will quantify important surface thermodynamic properties of materials. The hydrophobic effect and related phenomena, especially as this pertains to water solvent effects in biology, receives special emphasis. Course materials are drawn from a selection of relevant library reserve texts.
Note : Class size, frequency of offering, and evaluation methods will vary by location and instructor. For these details check the specific course syllabus.